IMPURITIES AVAILABLE FOR 'Calicheamicin'

Omsynth Lifesciences Pvt. Ltd. is one of the leading manufacturer and exporter of Calicheamicin. Calicheamicin is a highly potent enediyne antibiotic originally isolated from Micromonospora echinospora. It exerts its activity by binding to the minor groove of DNA and inducing double-strand breaks through radical-mediated cleavage. Due to this unique mechanism, it exhibits extreme cytotoxicity at picomolar concentrations. Calicheamicin itself is too toxic for direct therapeutic use, but it has been successfully applied in antibody–drug conjugates (ADCs), such as gemtuzumab ozogamicin, for targeted cancer therapy. It is particularly effective in treating acute myeloid leukemia (AML) and other hematologic malignancies when linked to monoclonal antibodies. The compound belongs to the enediyne class of natural products, known for their DNA-damaging ability. Handling requires great caution due to its high potency. Its discovery highlighted the potential of natural product–derived cytotoxins in oncology drug development. Buy high quality Calicheamicin from Omsynth Lifesciences.